Adenosine | 58-61-7

ʻO Adenosine, kahi nucleoside i haku ʻia me ka adenine a me ka ribose, he mau mea koʻikoʻi i ka lāʻau lapaʻau a me ka physiology ma muli o kona hopena physiological i nā ʻōnaehana like ʻole o ke kino.

ʻO ka lāʻau lapaʻau cardiovascular:

Mea Hana Diagnostic: Hoʻohana ʻia ʻo Adenosine ma ke ʻano he lāʻau koʻikoʻi lāʻau lapaʻau i ka wā o nā hoʻāʻo koʻikoʻi o ka naʻau, e like me ka myocardial perfusion imaging. Kōkua ia i ka loiloi ʻana i ka maʻi ʻaʻaʻa coronary ma o ka hoʻoulu ʻana i ka vasodilation coronary, e hoʻohālike ana i nā hopena o ka hoʻoikaika kino.

Hoʻomaʻamaʻa i ka Supraventricular Tachycardia (SVT): ʻO Adenosine kahi lāʻau lapaʻau mua no ka hoʻopau ʻana i nā ʻāpana SVT. Hoʻohana ia ma ka hoʻolohi ʻana i ka hoʻokele ʻana ma o ka node atrioventricular, ke hoʻopau i nā ala hoʻihoʻi i kuleana no SVT.

Neurology:

Manaʻo Paʻa: ʻO Adenosine kahi anticonvulsant endogenous i ka lolo. Hiki ke loaʻa nā hopena antiepileptic modulating adenosine receptors, a ke noiʻi ʻia nei nā mea hoʻokuʻu adenosine e like me nā lāʻau lapaʻau no ka epilepsy.

Neuroprotection: He kuleana ko nā mea loaʻa adenosine i ka pale ʻana i nā neurons mai ka hōʻeha ischemic a me ke kaumaha oxidative. Ke ʻimi nei ka noiʻi i ka hiki o ka adenosine ma ke ʻano he neuroprotective agent i ka hahau ʻana a me nā maʻi neurodegenerative e like me ka maʻi Parkinson a me Alzheimer.

Laau hanu hanu:

Bronchodilation: Hana ʻo Adenosine ma ke ʻano he bronchodilator a hoʻohana ʻia i ka hoʻāʻo bronchoprovocation e ʻike i ka hānō. Hoʻoulu ia i ka bronchoconstriction i nā poʻe me ka hānō, e kōkua ana e ʻike i ka hyperreactivity o ke ea.

Nā waiwai antiarrhythmic:

Hiki i ka Adenosine ke hoʻopau i kekahi mau ʻano arrhythmias ma o ka hoʻololi ʻana i ka hana uila i loko o ka puʻuwai, ʻo ia hoʻi ma ka atria a me ka atrioventricular node. ʻO kona hapalua ola pōkole e kaupalena i nā hopena ʻōnaehana.

Mea Hana Noiʻi:

Hoʻohana nui ʻia ʻo Adenosine a me kāna mau mea hoʻohālikelike i ka noiʻi e aʻo i ka hana o nā adenosine receptors i nā ʻano hana physiological a me nā pathological. Kōkua lākou i ka hoʻomaʻamaʻa ʻana i nā hana adenosine i ka neurotransmission, ka pane ʻana o ka immune, ka mumū, a me ka hoʻoponopono cardiovascular.

Nā hoʻohana lāʻau lapaʻau kūpono:

Ke noiʻi ʻia nei nā lāʻau lapaʻau e pili ana i ka Adenosine no nā noi therapeutic hiki ke loaʻa i nā kūlana e like me ke kanesa, ʻeha ischemic, mālama ʻeha, a me nā maʻi ʻeha. ʻO Adenosine receptor agonists a me nā antagonists kekahi o nā pūhui i aʻo ʻia.