D-Aspartic Acid | 1783-96-6

ʻO ka ʻakika Aspartic (i hoʻopau ʻia ʻo D-AA, Asp, a i ʻole D) he ʻakika α-amino me ke ʻano kemika HOOCCH(NH2)CH2COOH. ʻO ka anion carboxylate a me nā paʻakai o ka waikawa aspartic i ʻike ʻia he aspartate. ʻO ka L-isomer o ka aspartate kekahi o nā 22 proteinogenic amino acids, ʻo ia hoʻi, nā poloka kūkulu o nā protein. ʻO kona codons ʻo GAU a me GAC.
ʻO ka waikawa Aspartic, me ka glutamic acid, i helu ʻia ma ke ʻano he amino acidic me kahi pKa o 3.9, akā naʻe, i loko o kahi peptide, hilinaʻi nui ka pKa i ke kaiapuni kūloko. ʻO ka pKa kiʻekiʻe e like me 14 ʻaʻole ia he mea maʻamau. Loaʻa ka Aspartate i ka biosynthesis. E like me nā ʻakika amino āpau, pili ka loaʻa ʻana o nā protons acid i ke koena kemika kūloko a me ka pH o ka hopena.
ʻO ka waikawa aspartic kahi ʻano amino acid. Hoʻohana ʻia nā amino acids e like me nā poloka kūkulu e hana ai i ka protein i loko o ke kino. ʻAʻole hoʻohana ʻia kekahi ʻano aspartic acid, i kapa ʻia ʻo D-aspartic acid, e hana i ka protein, akā hoʻohana ʻia i nā hana ʻē aʻe o ke kino. ʻO ka waikawa Aspartic kahi waikawa α-amino i hoʻohana ʻia i ka biosynthesis o nā protein. E like me nā ʻakika amino ʻē aʻe, loaʻa iā ia kahi hui amino a me kahi waikawa carboxylic. ʻO D-Aspartic Acid kahi ʻano o ka waikawa amino alfa. Laha nui ia i ka biosynthesis o ka hana. Hiki ke hana ʻia ka ʻakika Aspartic mai ka ʻakika oxaloacetic ma o ka transamination. No nā mea kanu a me nā microorganism D-aspartic acid ka mea maka o nā ʻano amino acids, e like me methionine, threonine, isoleucine a me lysine.