Fludarabine | 21679-14-1

ʻO ka Fludarabine kahi lāʻau lapaʻau chemotherapy i hoʻohana mua ʻia i ka mālama ʻana i kekahi mau ʻano maʻi maʻi maʻi, ʻoi aku ka maʻi maʻi hematological. Eia kahi hiʻohiʻona:

Mechanism of Action: ʻO Fludarabine kahi analog nucleoside e hoʻopilikia i ka synthesis o DNA a me RNA. Kāohi ia i ka DNA polymerase, DNA primase, a me DNA ligase enzymes, e alakaʻi ana i ka haki ʻana o ke kaula DNA a me ka pale ʻana i nā hana hoʻoponopono DNA. ʻO kēia hoʻohaunaele o ka DNA synthesis e hoʻoulu i ka apoptosis (programmed cell death) i nā pūnaewele puʻunaue wikiwiki, e komo pū me nā maʻi kanesa.

Nā hōʻailona: Hoʻohana mau ʻia ka Fludarabine i ka mālama ʻana i ka maʻi maʻi lymphocytic maʻi (CLL), a me nā maʻi maʻi hematological ʻē aʻe e like me ka indolent non-Hodgkin lymphoma a me ka lymphoma cell mantle. Hiki ke hoʻohana ʻia i kekahi mau hihia o ka maʻi leukemia myeloid acute (AML).

Hoʻoponopono: Hoʻohana pinepine ʻia ʻo Fludarabine i loko o ke kino (IV) i loko o kahi kahua lapaʻau, ʻoiai hiki ke hāʻawi waha ʻia i kekahi mau hihia. ʻO ka nui a me ka papa manawa o ka hoʻoponopono ʻana e hilinaʻi ʻia i ke kanesa kikoʻī e mālama ʻia, a me ke olakino holoʻokoʻa o ka mea maʻi a me ka pane ʻana i ka mālama ʻana.

Nā hopena maikaʻi ʻole: ʻO nā hopena ʻaoʻao maʻamau o ka fludarabine ʻo ia ka hoʻopau ʻana i ka momona o ka iwi (e alakaʻi ana i ka neutropenia, anemia, a me ka thrombocytopenia), nausea, luaʻi, maʻi maʻi, ke kuni, ka luhi, a me ka hoʻonui ʻana i nā maʻi. Hiki iā ia ke hana i nā hopena koʻikoʻi e like me ka neurotoxicity, hepatotoxicity, a me ka pulmonary toxicity i kekahi mau hihia.

'Ōlelo Aʻo: Hoʻopaʻa ʻia ka Fludarabine i nā poʻe maʻi me ka hoʻopau ʻana i ka momona o ka iwi a i ʻole ka hana ʻana o ka renal. Pono e hoʻohana ʻia me ka akahele i nā mea maʻi me ka maʻi o ka ate a i ʻole nā ​​​​maʻi maʻi maʻi, a me nā wahine hāpai a hānai paha ma muli o ka hiki ke hōʻeha i ka fetus a i ʻole ka pēpē.

Hoʻopili i ka lāʻau lapaʻau: Hiki i ka Fludarabine ke launa pū me nā lāʻau lapaʻau ʻē aʻe, ʻo ia hoʻi nā mea e pili ana i ka hana o ka iwi iwi a i ʻole ka hana renal. He mea nui i nā mea mālama ola ke nānā pono i ka papa inoa o nā lāʻau lapaʻau o ka mea maʻi a nānā pono i nā pilina lāʻau.

Nānā: He mea nui ka nānā mau ʻana i nā helu koko a me ka hana renal i ka wā o ka mālama ʻana me ka fludarabine e nānā i nā hōʻailona o ka hoʻopau ʻana i ka momona o ka iwi a i ʻole nā ​​hopena ʻino ʻē aʻe. Pono paha ka hoʻololi ʻana ma muli o kēia mau ʻāpana nānā.