Huperzine A ｜120786-18-7
Hōʻike huahana:
ʻO Huperzine A kahi mea hoʻonui cognitive e kāohi i nā enzyme e hoʻohaʻahaʻa i ka acetylcholine neurotransmitter aʻo. Aia ia i ka papa cholinergic o nā molekole e hiki ke kōkua i ka pale ʻana i ka emi ʻana o ka cognitive i ka poʻe ʻelemakule.
ʻO Huperzine A kahi hui i lawe ʻia mai ka ʻohana huperzine. Ua kapa ʻia ʻo ia he acetylcholinesterase inhibitor, ʻo ia ka mea e pale ai i ka enzyme mai ka wāwahi ʻana i ka acetylcholine, e alakaʻi ana i ka piʻi ʻana o ka acetylcholine.
Ua kapa ʻia ʻo Acetylcholine he neurotransmitter aʻo a pili pū kekahi i nā ʻokiʻoki.
ʻIke ʻia ʻo Huperzine A he pūhui palekana. ʻAʻole i hōʻike ʻia ka ʻona a me nā haʻawina kanaka mai nā haʻawina holoholona i nā hopena ʻaoʻao ma nā ʻano hoʻohui maʻamau. Hoʻohana ʻia ʻo Huperzine A i nā hoʻokolohua mua e pale ai i ka maʻi o Alzheimer.
Loaʻa ka Huperzine A i ka wai cerebrospinal a hele maʻalahi i ka pale koko-lolo.
ʻO Huperzine A ka mea i ʻike maikaʻi ʻia ma ke ʻano he acetylcholinesterase inhibitor. ʻO ka mea kūikawā, ke kāohi nei ia i ka subtype G4 o acetylcholinesterase, ka mea maʻamau i nā lolo mammalian. ʻOi aku ka maikaʻi a i ʻole ka maikaʻi e kūʻē i nā mea hoʻopaneʻe acetylcholinesterase, e like me tacillin a i ʻole rivastatin. Ma ke ʻano he mea paʻa, loaʻa iā ia kahi pilina kiʻekiʻe no ka acetylcholinesterase. I ka manawa like, loaʻa ka dissociation lohi, e hoʻolōʻihi i kona hapalua ola.
Ma waho aʻe o ka pale ʻana i ka acetylcholinesterase, hiki ke ʻike ʻia he neuroprotective kūʻē i ka glutamate, beta amyloid pigmentation, a me ka H2O2-induced toxicity.
Hiki i ka Huperzine A ke hoʻoikaika i ka hoʻonui ʻana o nā pūpū neural stem hippocampal (NSCs). Me he mea lā e hoʻoikaika i ka ulu ʻana o ke aʻalolo ma nā ʻano biorelated.
