Tacrolimus | 104987-11-3

ʻO Tacrolimus, ka mea i ʻike ʻia e kona inoa kālepa ʻo Prograf ma waena o nā mea ʻē aʻe, he lāʻau immunosuppressive ikaika i hoʻohana mua ʻia i ka hoʻololi ʻana o ke kino e pale ai i ka hōʻole.

Mechanism of Action: Hana ʻo Tacrolimus ma ke kāohi ʻana i ka calcineurin, kahi protein phosphatase e hana koʻikoʻi i ka hoʻāla ʻana o nā T-lymphocytes, ʻo ia nā cell immune i komo i ka hōʻole ʻana. Ma ka pale ʻana i ka calcineurin, hoʻopaʻa ʻo tacrolimus i ka hana ʻana o nā cytokines pro-inflammatory a pale i ka hoʻāla ʻana o nā T-cell, a laila e hoʻopaʻa i ka pane ʻana mai i ke kino transplanted.

Nā hōʻailona: hōʻike ʻia ʻo Tacrolimus no ka prophylaxis o ka hōʻole ʻana o ke kino i nā poʻe maʻi e loaʻa ana i ka allogeneic ate, kidney, a me nā transplants naʻau. Hoʻohana pinepine ʻia me ka hui pū ʻana me nā mea immunosuppressive ʻē aʻe e like me corticosteroids a me mycophenolate mofetil.

Hoʻoponopono: Hoʻohana maʻamau ʻia ʻo Tacrolimus ma ke ʻano o nā capsules a i ʻole ka hopena waha. Hiki ke lawelawe ʻia me ka intravenously i kekahi mau kūlana lapaʻau, e like me ka wā ma hope o ka hoʻololi koke ʻana.

Ka nānā ʻana: Ma muli o kāna ʻōlelo kuhikuhi therapeutic haiki a me ka ʻokoʻa o ka absorption, pono ka tacrolimus i ka nānā pono ʻana i nā pae koko e hōʻoia i ka maikaʻi o ka lāʻau lapaʻau me ka hōʻemi ʻana i ka hopena o ka ʻona. ʻO ka nānā ʻana i ka lāʻau lapaʻau Therapeutic e pili ana i ke ana maʻamau o nā pae koko tacrolimus a me ka hoʻoponopono ʻana i ka maʻi ma muli o kēia mau pae.

Nā hopena maikaʻi ʻole: ʻO nā hopena ʻaoʻao maʻamau o ka tacrolimus e pili ana i ka nephrotoxicity, neurotoxicity, hypertension, hyperglycemia, gastrointestinal disturbances, a me ka piʻi ʻana o ka maʻi i nā maʻi. ʻO ka hoʻohana lōʻihi ʻana i ka tacrolimus hiki ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i kekahi mau maʻi ʻino, ʻoi aku ka maʻi maʻi ʻili a me ka lymphoma.

Hoʻopili i nā lāʻau lapaʻau: Hoʻopili ʻia ʻo Tacrolimus e ka ʻōnaehana enzyme cytochrome P450, ʻoi aku ka CYP3A4 a me CYP3A5. No laila, hiki i nā lāʻau lapaʻau e hoʻoulu ai a keʻakeʻa paha i kēia mau enzymes hiki ke hoʻopilikia i nā pae tacrolimus i loko o ke kino, hiki ke alakaʻi i ka hopena therapeutic a i ʻole ka make.

Nā Manaʻo Kūikawā: Pono ka hoʻohana ʻana o Tacrolimus i kēlā me kēia kanaka ma muli o nā kumu e like me ka makahiki o ka maʻi, ke kaumaha o ke kino, ka hana renal, nā lāʻau i hui pū ʻia, a me ka hele ʻana o nā co-morbidities. He mea nui ka nānā ʻana a me ka hahai mau ʻana me nā mea mālama olakino no ka hoʻonui ʻana i ka lāʻau lapaʻau a me ka hōʻemi ʻana i nā hopena ʻino.